2nd COMPONENT PROJECT
Coordinator Institution:
UNIVERSITY POLITEHNICA OF BUCHAREST
Project Responsable : Prof. univ. dr. Berger Daniela-Cristina
Project objectives
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Method of obtaining functionalized mesoporous silica with controlled pore size
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Obtaining laboratory composite materials with embedded protein extract
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Method of obtaining TiO2
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Obtaining at laboratory level composite materials with embedded protein extract
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Obtaining laboratory-functionalized silica supports at the laboratory level of a functional composite material Laboratory development of cellular effects assessment
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Patented technology for laboratory-grade production of a functional material Incorporating and controlled release of natural extracts from mesoporous matrices
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Laboratory development of encapsulation technology for bio-extracts
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Incorporating and controlled release of natural extracts from mesoporous matrices
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Developed at laboratory level
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Resveratrol extraction technology at laboratory level
Project Stages
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Stage 1/2018
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Elaboration of experimental methods for obtaining extracts with pharmaceutical potential from marine sources and technologies for realization of mesoporous inorganic supports for their encapsulation
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Stage 2/2019
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Obtaining and characterization of natural bioactive compounds and their encapsulation in mesoporous matrices with pharmaceutical and bioregenerative evaluation
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Stage 3/2020
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Developing dermatologically-cosmetic and pharmaceutical products based on marine resources with synergic action and demonstrating their functionality.
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STAGE 1/2018
Project activities
Activity 1.4.
Synthesis and characterization of functionalized mesoporous silica
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Indicators of achievement: 4 types of pure silica particles, 4 types of silica functionalized with organic groups, 2 types of Zn and Mg-modified silica, characterized by textural parameters, particle size, chemical composition
Activity 1.5.
Biocompatibility assessment of functionalized mesoporous silica supports
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Indicators of achievement: 1 cell viability report
Activity 1.6.
Harvesting, preparation and characterization of marine raw materials of plant origin
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Indicators of achievement: 1 selected marine organism, species of green algae Ulva rigida (sin. Ulva lactuca) 2 fluid extracts in different solvents 2 pesticide content analysis bulletins, heavy metal content, biochemical composition 1 analysis bulletin for antimicrobial activity 1 analysis bulletin for antioxidant activity
STAGE 2/2019
2nd COMPONENT PROJECT
Activity 2.1. and Activity 2.2. Activity name: Obtaining and characterizing bio-extracts using advanced technologies
Achievement indicators: extraction technological parameters for polyphenolic extracts, polyphenol extraction technology from tescovina, protein extract, protein extraction technology, green algae polysaccharide extraction technology; chemical profile of polyphenolic extracts, antioxidant activities, metal content, metal content, pesticides.
Activity 2.3. Activity name: Technologies for encapsulation / incorporation of bioextracts in mesoporous matrices and characterization of the composites obtained
Indicators of achievement: pure and functionalized mesoporous polyphenolic-silica extract composites; pure and functionalized collagen-silica composites; chemical compositions, structural features, morphology, thermally established, antioxidant activity, in vitro release profiles.
Activity 2.4. Activity name: Biologically evaluated composites with encapsulated bioextracts
Indicators of achievement: cell viability for free and encapsulated polyphenolic extracts in mesoporous matrices; 1 analysis report for a polysaccharide extract from Ulva lactuca, 1 analysis report for antimicrobial activities
Activity 2.5. Activity Name: Preliminary formulations of pharmaceutical / bioregenerative products and their testing
Indicators of achievement: 1 preliminary pharmaceutical formulation - 4 preliminary pharmaceutical formulations were made.
Activity 2.6. Activity name: Technologies for recovery and recovery of residual marine biomass in viticulture
Performance indicators: residual marine biomass - algal (green algae), animal (shells) and residual biomass (tescovina); a technological variant for obtaining 1 biostimulator-regenerator for vineyards.
3 rd STAGE
COMPONENT PROJECT NO. 2
• Activity 3.6.: Separation from natural extracts of components with synergistic action and their biochemical characterization - Part 1
Achievement indicators:
• extracted technological parameters - partially
• Activity 3.7.: Incorporation of a cytostatic agent into the mesopores of the functionalized silica-type matrix with compounds from natural extracts and characterization of the resulting composites - Part 1
Achievement indicators:
• 1 functionalized mesoporous matrix of silica type
• Activity 3.8.: Assessment of the influence of the natural extract on the in vitro release profiles of the cytostatic agent - Part 1
Achievement indicators:
• kinetic parameters - partially
• Activity 3.9.: Evaluation of the synergistic activity of the cytostatic agent and the component of the marine extract on cell cultures - Part 1
Achievement indicators:
• 1 analysis report for cell viability
• 1 cell morphology report
• Activity 3.10.: Formulation of pharmaceutical / bioregenerative products - Part 1
Achievement indicators:
• 1 pharmaceutical product
• 1 analysis bulletin for antimicrobial activity
• Activity 3.13.: Widespread dissemination through national or international communication and publication of results - Part 1
Achievement indicators:
• 2 papers communicated at scientific events
• Activity 3.14.: Innovation activity and patent application - Part 1
Achievement indicators:
• 1 patent application
Stage no. III / 2020 - Dissemination of results
Component project no. 2
PATENT OF INVENTION
- "Topical dermato-cosmetic preparations of the type bioadhesive gels with dermal tissue regeneration effect", National Patent Application, OSIM, 2020