PROJECT OBJECTIVE 

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The scope of project INOBIOMAR is application of some innovative technologies in drug delivery systems for the development of bioregenerative pharmaceutical formulation and dermato-cosmetic products by encapsulating bioactive compounds presents in marine organisms and residual wine biomass from the Black Sea region in mesoporous structures, to assess their effects at the cellular level and also the antimicrobial and antioxidant level.

 

COMPLEX PROJECT ABSTRACT

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Natural products from marine species are increasingly studied as their functional properties are discovered. These properties have benefits for human health while depending on their geographical region of origin. As abundant marine resources with insufficiently exploited therapeutic potential exist, the present proposal aims to harness the Black Sea bioresources through developing innovative technologies for obtaining biorenewable pharmaceutics preparations. The membrane/bioadhesive disks preparations consist of bioactive compounds from marine extracts encapsulated into mesoporous functionalized silica matrices and have controlled release. The Black Sea bioresources valorization will be improved by using the residual biomass from technological flux as biofertilizer for vineyards. New technologies for efficient extraction and preservation of active ingredients, encapsulation in pharmaceutical and nanostructured silica matrices, obtaining modern, therapeutically/cosmetic efficient formulations tested in vitro, will be developed. The project will be completed by a multidisciplinary consortium composed of UOC, INCDM, UPB, INCDSB, having a new research center with personnel deficit (Romanian Academy-ICF) and a relaunching center- SCDVV Murtfatlar, which will develop and use the common infrastructure, existing and newly created human resources, both through the project implementation and future collaborations, while strengthening the partners’ institutional capacity through improving their services offers. The project will achieve TRL 5. The main goal of the complex project can be achieved through the complementarity of the 5 component projects, having 6 patent applications and developing new fabrication technologies for 3 pharmaceutical formulations with synergetic action as deliverables, which can be translated to economic beneficiaries.

 

ESTIMATED RESULTS

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Marine organisms rich in bioactive compounds, biotechnologies for protein and polysaccharide extraction, tests of biological effects, antimicrobial effects, protocol of biological waste processing, in vitro experimental models for the evaluation of regenerative effect, antiinflammatory and antitumoral, mesoporous silica powders, parameters optimal technological methods, encapsulation methods, embedding methods, cell viability tests, antioxidant activity, technologies for obtaining of mesoporous pristine and functionalized silica -bio-extract composites / TiO2-bio-extract composites, residual biomass, 3 pharmaceutical and dermato-cosmetics formulations with bioregenerative / antimicrobial / antitumor effect, technology for obtaining a biostimulator-regenerator product, 10 conferences attending, 6 ISI/BDI articles, 4 patent applications.